Description:

The package implements a method for normalising microarray intensities,
both between colours within array, and between arrays. The method uses a
robust variant of the maximum-likelihood estimator for the stochastic
model of microarray data described in the references (see vignette). The
model incorporates data calibration (a.k.a. normalization), a model for
the dependence of the variance on the mean intensity, and a variance
stabilizing data transformation. Differences between transformed
intensities are analogous to "normalized log-ratios". However, in contrast
to the latter, their variance is independent of the mean, and they are
usually more sensitive and specific in detecting differential