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Module ProtParamData
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<h1 class="epydoc">Source Code for <a href="Bio.SeqUtils.ProtParamData-module.html">Module Bio.SeqUtils.ProtParamData</a></h1>
<pre class="py-src">
<a name="L1"></a><tt class="py-lineno"> 1</tt> <tt class="py-line"><tt class="py-comment"># This module contains indices to be used with ProtParam</tt> </tt>
<a name="L2"></a><tt class="py-lineno"> 2</tt> <tt class="py-line"><tt class="py-comment"></tt> </tt>
<a name="L3"></a><tt class="py-lineno"> 3</tt> <tt class="py-line"><tt class="py-comment"># Kyte & Doolittle index of hydrophobicity</tt> </tt>
<a name="L4"></a><tt class="py-lineno"> 4</tt> <tt class="py-line"><tt class="py-comment"></tt><tt id="link-0" class="py-name" targets="Variable Bio.SeqUtils.ProtParamData.kd=Bio.SeqUtils.ProtParamData-module.html#kd"><a title="Bio.SeqUtils.ProtParamData.kd" class="py-name" href="#" onclick="return doclink('link-0', 'kd', 'link-0');">kd</a></tt> <tt class="py-op">=</tt> <tt class="py-op">{</tt> <tt class="py-string">'A'</tt><tt class="py-op">:</tt> <tt class="py-number">1.8</tt><tt class="py-op">,</tt><tt class="py-string">'R'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">4.5</tt><tt class="py-op">,</tt><tt class="py-string">'N'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">3.5</tt><tt class="py-op">,</tt><tt class="py-string">'D'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">3.5</tt><tt class="py-op">,</tt><tt class="py-string">'C'</tt><tt class="py-op">:</tt> <tt class="py-number">2.5</tt><tt class="py-op">,</tt> </tt>
<a name="L5"></a><tt class="py-lineno"> 5</tt> <tt class="py-line"> <tt class="py-string">'Q'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">3.5</tt><tt class="py-op">,</tt><tt class="py-string">'E'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">3.5</tt><tt class="py-op">,</tt><tt class="py-string">'G'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">0.4</tt><tt class="py-op">,</tt><tt class="py-string">'H'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">3.2</tt><tt class="py-op">,</tt><tt class="py-string">'I'</tt><tt class="py-op">:</tt> <tt class="py-number">4.5</tt><tt class="py-op">,</tt> </tt>
<a name="L6"></a><tt class="py-lineno"> 6</tt> <tt class="py-line"> <tt class="py-string">'L'</tt><tt class="py-op">:</tt> <tt class="py-number">3.8</tt><tt class="py-op">,</tt><tt class="py-string">'K'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">3.9</tt><tt class="py-op">,</tt><tt class="py-string">'M'</tt><tt class="py-op">:</tt> <tt class="py-number">1.9</tt><tt class="py-op">,</tt><tt class="py-string">'F'</tt><tt class="py-op">:</tt> <tt class="py-number">2.8</tt><tt class="py-op">,</tt><tt class="py-string">'P'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">1.6</tt><tt class="py-op">,</tt> </tt>
<a name="L7"></a><tt class="py-lineno"> 7</tt> <tt class="py-line"> <tt class="py-string">'S'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">0.8</tt><tt class="py-op">,</tt><tt class="py-string">'T'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">0.7</tt><tt class="py-op">,</tt><tt class="py-string">'W'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">0.9</tt><tt class="py-op">,</tt><tt class="py-string">'Y'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">1.3</tt><tt class="py-op">,</tt><tt class="py-string">'V'</tt><tt class="py-op">:</tt> <tt class="py-number">4.2</tt> <tt class="py-op">}</tt> </tt>
<a name="L8"></a><tt class="py-lineno"> 8</tt> <tt class="py-line"> </tt>
<a name="L9"></a><tt class="py-lineno"> 9</tt> <tt class="py-line"><tt class="py-comment"># Flexibility</tt> </tt>
<a name="L10"></a><tt class="py-lineno">10</tt> <tt class="py-line"><tt class="py-comment"></tt><tt class="py-comment"># Normalized flexibility parameters (B-values), average (Vihinen et al., 1994)</tt> </tt>
<a name="L11"></a><tt class="py-lineno">11</tt> <tt class="py-line"><tt class="py-comment"></tt><tt id="link-1" class="py-name" targets="Variable Bio.SeqUtils.ProtParamData.Flex=Bio.SeqUtils.ProtParamData-module.html#Flex"><a title="Bio.SeqUtils.ProtParamData.Flex" class="py-name" href="#" onclick="return doclink('link-1', 'Flex', 'link-1');">Flex</a></tt><tt class="py-op">=</tt> <tt class="py-op">{</tt><tt class="py-string">'A'</tt><tt class="py-op">:</tt> <tt class="py-number">0.984</tt><tt class="py-op">,</tt> <tt class="py-string">'C'</tt><tt class="py-op">:</tt> <tt class="py-number">0.906</tt><tt class="py-op">,</tt> <tt class="py-string">'E'</tt><tt class="py-op">:</tt> <tt class="py-number">1.094</tt><tt class="py-op">,</tt> <tt class="py-string">'D'</tt><tt class="py-op">:</tt> <tt class="py-number">1.068</tt><tt class="py-op">,</tt> </tt>
<a name="L12"></a><tt class="py-lineno">12</tt> <tt class="py-line"> <tt class="py-string">'G'</tt><tt class="py-op">:</tt> <tt class="py-number">1.031</tt><tt class="py-op">,</tt> <tt class="py-string">'F'</tt><tt class="py-op">:</tt> <tt class="py-number">0.915</tt><tt class="py-op">,</tt> <tt class="py-string">'I'</tt><tt class="py-op">:</tt> <tt class="py-number">0.927</tt><tt class="py-op">,</tt> <tt class="py-string">'H'</tt><tt class="py-op">:</tt> <tt class="py-number">0.950</tt><tt class="py-op">,</tt> </tt>
<a name="L13"></a><tt class="py-lineno">13</tt> <tt class="py-line"> <tt class="py-string">'K'</tt><tt class="py-op">:</tt> <tt class="py-number">1.102</tt><tt class="py-op">,</tt> <tt class="py-string">'M'</tt><tt class="py-op">:</tt> <tt class="py-number">0.952</tt><tt class="py-op">,</tt> <tt class="py-string">'L'</tt><tt class="py-op">:</tt> <tt class="py-number">0.935</tt><tt class="py-op">,</tt> <tt class="py-string">'N'</tt><tt class="py-op">:</tt> <tt class="py-number">1.048</tt><tt class="py-op">,</tt> </tt>
<a name="L14"></a><tt class="py-lineno">14</tt> <tt class="py-line"> <tt class="py-string">'Q'</tt><tt class="py-op">:</tt> <tt class="py-number">1.037</tt><tt class="py-op">,</tt> <tt class="py-string">'P'</tt><tt class="py-op">:</tt> <tt class="py-number">1.049</tt><tt class="py-op">,</tt> <tt class="py-string">'S'</tt><tt class="py-op">:</tt> <tt class="py-number">1.046</tt><tt class="py-op">,</tt> <tt class="py-string">'R'</tt><tt class="py-op">:</tt> <tt class="py-number">1.008</tt><tt class="py-op">,</tt> </tt>
<a name="L15"></a><tt class="py-lineno">15</tt> <tt class="py-line"> <tt class="py-string">'T'</tt><tt class="py-op">:</tt> <tt class="py-number">0.997</tt><tt class="py-op">,</tt> <tt class="py-string">'W'</tt><tt class="py-op">:</tt> <tt class="py-number">0.904</tt><tt class="py-op">,</tt> <tt class="py-string">'V'</tt><tt class="py-op">:</tt> <tt class="py-number">0.931</tt><tt class="py-op">,</tt> <tt class="py-string">'Y'</tt><tt class="py-op">:</tt> <tt class="py-number">0.929</tt><tt class="py-op">}</tt> </tt>
<a name="L16"></a><tt class="py-lineno">16</tt> <tt class="py-line"> </tt>
<a name="L17"></a><tt class="py-lineno">17</tt> <tt class="py-line"><tt class="py-comment"># Hydrophilicity</tt> </tt>
<a name="L18"></a><tt class="py-lineno">18</tt> <tt class="py-line"><tt class="py-comment"></tt><tt class="py-comment"># 1 Hopp & Wood</tt> </tt>
<a name="L19"></a><tt class="py-lineno">19</tt> <tt class="py-line"><tt class="py-comment"></tt><tt class="py-comment"># Proc. Natl. Acad. Sci. U.S.A. 78:3824-3828(1981). </tt> </tt>
<a name="L20"></a><tt class="py-lineno">20</tt> <tt class="py-line"><tt class="py-comment"></tt><tt id="link-2" class="py-name" targets="Variable Bio.SeqUtils.ProtParamData.hw=Bio.SeqUtils.ProtParamData-module.html#hw"><a title="Bio.SeqUtils.ProtParamData.hw" class="py-name" href="#" onclick="return doclink('link-2', 'hw', 'link-2');">hw</a></tt> <tt class="py-op">=</tt> <tt class="py-op">{</tt> <tt class="py-string">'A'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">0.5</tt><tt class="py-op">,</tt><tt class="py-string">'R'</tt><tt class="py-op">:</tt><tt class="py-number">3.0</tt><tt class="py-op">,</tt> <tt class="py-string">'N'</tt><tt class="py-op">:</tt><tt class="py-number">0.2</tt><tt class="py-op">,</tt> <tt class="py-string">'D'</tt><tt class="py-op">:</tt><tt class="py-number">3.0</tt><tt class="py-op">,</tt> <tt class="py-string">'C'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">1.0</tt><tt class="py-op">,</tt> </tt>
<a name="L21"></a><tt class="py-lineno">21</tt> <tt class="py-line"> <tt class="py-string">'Q'</tt><tt class="py-op">:</tt><tt class="py-number">0.2</tt><tt class="py-op">,</tt> <tt class="py-string">'E'</tt><tt class="py-op">:</tt><tt class="py-number">3.0</tt><tt class="py-op">,</tt> <tt class="py-string">'G'</tt><tt class="py-op">:</tt><tt class="py-number">0.0</tt><tt class="py-op">,</tt> <tt class="py-string">'H'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">0.5</tt><tt class="py-op">,</tt><tt class="py-string">'I'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">1.8</tt><tt class="py-op">,</tt> </tt>
<a name="L22"></a><tt class="py-lineno">22</tt> <tt class="py-line"> <tt class="py-string">'L'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">1.8</tt><tt class="py-op">,</tt><tt class="py-string">'K'</tt><tt class="py-op">:</tt><tt class="py-number">3.0</tt><tt class="py-op">,</tt> <tt class="py-string">'M'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">1.3</tt><tt class="py-op">,</tt><tt class="py-string">'F'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">2.5</tt><tt class="py-op">,</tt><tt class="py-string">'P'</tt><tt class="py-op">:</tt><tt class="py-number">0.0</tt><tt class="py-op">,</tt> </tt>
<a name="L23"></a><tt class="py-lineno">23</tt> <tt class="py-line"> <tt class="py-string">'S'</tt><tt class="py-op">:</tt><tt class="py-number">0.3</tt><tt class="py-op">,</tt> <tt class="py-string">'T'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">0.4</tt><tt class="py-op">,</tt><tt class="py-string">'W'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">3.4</tt><tt class="py-op">,</tt><tt class="py-string">'Y'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">2.3</tt><tt class="py-op">,</tt><tt class="py-string">'V'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">1.5</tt> <tt class="py-op">}</tt> </tt>
<a name="L24"></a><tt class="py-lineno">24</tt> <tt class="py-line"> </tt>
<a name="L25"></a><tt class="py-lineno">25</tt> <tt class="py-line"><tt class="py-comment"># Surface accessibility</tt> </tt>
<a name="L26"></a><tt class="py-lineno">26</tt> <tt class="py-line"><tt class="py-comment"></tt><tt class="py-comment"># 1 Emini Surface fractional probability</tt> </tt>
<a name="L27"></a><tt class="py-lineno">27</tt> <tt class="py-line"><tt class="py-comment"></tt><tt id="link-3" class="py-name" targets="Variable Bio.SeqUtils.ProtParamData.em=Bio.SeqUtils.ProtParamData-module.html#em"><a title="Bio.SeqUtils.ProtParamData.em" class="py-name" href="#" onclick="return doclink('link-3', 'em', 'link-3');">em</a></tt> <tt class="py-op">=</tt> <tt class="py-op">{</tt> <tt class="py-string">'A'</tt><tt class="py-op">:</tt><tt class="py-number">0.815</tt><tt class="py-op">,</tt><tt class="py-string">'R'</tt><tt class="py-op">:</tt><tt class="py-number">1.475</tt><tt class="py-op">,</tt><tt class="py-string">'N'</tt><tt class="py-op">:</tt><tt class="py-number">1.296</tt><tt class="py-op">,</tt><tt class="py-string">'D'</tt><tt class="py-op">:</tt><tt class="py-number">1.283</tt><tt class="py-op">,</tt><tt class="py-string">'C'</tt><tt class="py-op">:</tt><tt class="py-number">0.394</tt><tt class="py-op">,</tt> </tt>
<a name="L28"></a><tt class="py-lineno">28</tt> <tt class="py-line"> <tt class="py-string">'Q'</tt><tt class="py-op">:</tt><tt class="py-number">1.348</tt><tt class="py-op">,</tt><tt class="py-string">'E'</tt><tt class="py-op">:</tt><tt class="py-number">1.445</tt><tt class="py-op">,</tt><tt class="py-string">'G'</tt><tt class="py-op">:</tt><tt class="py-number">0.714</tt><tt class="py-op">,</tt><tt class="py-string">'H'</tt><tt class="py-op">:</tt><tt class="py-number">1.180</tt><tt class="py-op">,</tt><tt class="py-string">'I'</tt><tt class="py-op">:</tt><tt class="py-number">0.603</tt><tt class="py-op">,</tt> </tt>
<a name="L29"></a><tt class="py-lineno">29</tt> <tt class="py-line"> <tt class="py-string">'L'</tt><tt class="py-op">:</tt><tt class="py-number">0.603</tt><tt class="py-op">,</tt><tt class="py-string">'K'</tt><tt class="py-op">:</tt><tt class="py-number">1.545</tt><tt class="py-op">,</tt><tt class="py-string">'M'</tt><tt class="py-op">:</tt><tt class="py-number">0.714</tt><tt class="py-op">,</tt><tt class="py-string">'F'</tt><tt class="py-op">:</tt><tt class="py-number">0.695</tt><tt class="py-op">,</tt><tt class="py-string">'P'</tt><tt class="py-op">:</tt><tt class="py-number">1.236</tt><tt class="py-op">,</tt> </tt>
<a name="L30"></a><tt class="py-lineno">30</tt> <tt class="py-line"> <tt class="py-string">'S'</tt><tt class="py-op">:</tt><tt class="py-number">1.115</tt><tt class="py-op">,</tt><tt class="py-string">'T'</tt><tt class="py-op">:</tt><tt class="py-number">1.184</tt><tt class="py-op">,</tt><tt class="py-string">'W'</tt><tt class="py-op">:</tt><tt class="py-number">0.808</tt><tt class="py-op">,</tt><tt class="py-string">'Y'</tt><tt class="py-op">:</tt><tt class="py-number">1.089</tt><tt class="py-op">,</tt><tt class="py-string">'V'</tt><tt class="py-op">:</tt><tt class="py-number">0.606</tt> <tt class="py-op">}</tt> </tt>
<a name="L31"></a><tt class="py-lineno">31</tt> <tt class="py-line"> </tt>
<a name="L32"></a><tt class="py-lineno">32</tt> <tt class="py-line"><tt class="py-comment"># 2 Janin Interior to surface transfer energy scale</tt> </tt>
<a name="L33"></a><tt class="py-lineno">33</tt> <tt class="py-line"><tt class="py-comment"></tt><tt id="link-4" class="py-name" targets="Variable Bio.SeqUtils.ProtParamData.ja=Bio.SeqUtils.ProtParamData-module.html#ja"><a title="Bio.SeqUtils.ProtParamData.ja" class="py-name" href="#" onclick="return doclink('link-4', 'ja', 'link-4');">ja</a></tt> <tt class="py-op">=</tt> <tt class="py-op">{</tt> <tt class="py-string">'A'</tt><tt class="py-op">:</tt> <tt class="py-number">0.28</tt><tt class="py-op">,</tt><tt class="py-string">'R'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">1.14</tt><tt class="py-op">,</tt><tt class="py-string">'N'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">0.55</tt><tt class="py-op">,</tt><tt class="py-string">'D'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">0.52</tt><tt class="py-op">,</tt><tt class="py-string">'C'</tt><tt class="py-op">:</tt> <tt class="py-number">0.97</tt><tt class="py-op">,</tt> </tt>
<a name="L34"></a><tt class="py-lineno">34</tt> <tt class="py-line"> <tt class="py-string">'Q'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">0.69</tt><tt class="py-op">,</tt><tt class="py-string">'E'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">1.01</tt><tt class="py-op">,</tt><tt class="py-string">'G'</tt><tt class="py-op">:</tt> <tt class="py-number">0.43</tt><tt class="py-op">,</tt><tt class="py-string">'H'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">0.31</tt><tt class="py-op">,</tt><tt class="py-string">'I'</tt><tt class="py-op">:</tt> <tt class="py-number">0.60</tt><tt class="py-op">,</tt> </tt>
<a name="L35"></a><tt class="py-lineno">35</tt> <tt class="py-line"> <tt class="py-string">'L'</tt><tt class="py-op">:</tt> <tt class="py-number">0.60</tt><tt class="py-op">,</tt><tt class="py-string">'K'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">1.62</tt><tt class="py-op">,</tt><tt class="py-string">'M'</tt><tt class="py-op">:</tt> <tt class="py-number">0.43</tt><tt class="py-op">,</tt><tt class="py-string">'F'</tt><tt class="py-op">:</tt> <tt class="py-number">0.46</tt><tt class="py-op">,</tt><tt class="py-string">'P'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">0.42</tt><tt class="py-op">,</tt> </tt>
<a name="L36"></a><tt class="py-lineno">36</tt> <tt class="py-line"> <tt class="py-string">'S'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">0.19</tt><tt class="py-op">,</tt><tt class="py-string">'T'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">0.32</tt><tt class="py-op">,</tt><tt class="py-string">'W'</tt><tt class="py-op">:</tt> <tt class="py-number">0.29</tt><tt class="py-op">,</tt><tt class="py-string">'Y'</tt><tt class="py-op">:</tt><tt class="py-op">-</tt><tt class="py-number">0.15</tt><tt class="py-op">,</tt><tt class="py-string">'V'</tt><tt class="py-op">:</tt> <tt class="py-number">0.60</tt> <tt class="py-op">}</tt> </tt>
<a name="L37"></a><tt class="py-lineno">37</tt> <tt class="py-line"> </tt>
<a name="L38"></a><tt class="py-lineno">38</tt> <tt class="py-line"> </tt>
<a name="L39"></a><tt class="py-lineno">39</tt> <tt class="py-line"><tt class="py-comment"># A two dimentional dictionary for calculating the instability index.</tt> </tt>
<a name="L40"></a><tt class="py-lineno">40</tt> <tt class="py-line"><tt class="py-comment"></tt><tt class="py-comment"># Guruprasad K., Reddy B.V.B., Pandit M.W. Protein Engineering 4:155-161(1990).</tt> </tt>
<a name="L41"></a><tt class="py-lineno">41</tt> <tt class="py-line"><tt class="py-comment"></tt><tt class="py-comment"># It is based on dipeptide values therefore the vale for the dipeptide DG is DIWV['D']['G'].</tt> </tt>
<a name="L42"></a><tt class="py-lineno">42</tt> <tt class="py-line"><tt class="py-comment"></tt><tt class="py-comment"># I know this looks ugly but i can't think of a better way to display it.</tt> </tt>
<a name="L43"></a><tt class="py-lineno">43</tt> <tt class="py-line"><tt class="py-comment"></tt><tt id="link-5" class="py-name" targets="Variable Bio.SeqUtils.ProtParamData.DIWV=Bio.SeqUtils.ProtParamData-module.html#DIWV"><a title="Bio.SeqUtils.ProtParamData.DIWV" class="py-name" href="#" onclick="return doclink('link-5', 'DIWV', 'link-5');">DIWV</a></tt> <tt class="py-op">=</tt> <tt class="py-op">{</tt><tt class="py-string">'A'</tt><tt class="py-op">:</tt> <tt class="py-op">{</tt><tt class="py-string">'A'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'C'</tt><tt class="py-op">:</tt> <tt class="py-number">44.94</tt><tt class="py-op">,</tt> <tt class="py-string">'E'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'D'</tt><tt class="py-op">:</tt> <tt class="py-op">-</tt><tt class="py-number">7.49</tt><tt class="py-op">,</tt> <tt class="py-string">'G'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'F'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'I'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'H'</tt><tt class="py-op">:</tt> <tt class="py-op">-</tt><tt class="py-number">7.49</tt><tt class="py-op">,</tt> <tt class="py-string">'K'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'M'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'L'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'N'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'Q'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'P'</tt><tt class="py-op">:</tt> <tt class="py-number">20.26</tt><tt class="py-op">,</tt> <tt class="py-string">'S'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'R'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'T'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'W'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'V'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'Y'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">}</tt><tt class="py-op">,</tt><tt class="py-string">'C'</tt><tt class="py-op">:</tt> <tt class="py-op">{</tt><tt class="py-string">'A'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'C'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'E'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'D'</tt><tt class="py-op">:</tt> <tt class="py-number">20.26</tt><tt class="py-op">,</tt> <tt class="py-string">'G'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'F'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'I'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'H'</tt><tt class="py-op">:</tt> <tt class="py-number">33.60</tt><tt class="py-op">,</tt> <tt class="py-string">'K'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'M'</tt><tt class="py-op">:</tt> <tt class="py-number">33.60</tt><tt class="py-op">,</tt> <tt class="py-string">'L'</tt><tt class="py-op">:</tt> <tt class="py-number">20.26</tt><tt class="py-op">,</tt> <tt class="py-string">'N'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'Q'</tt><tt class="py-op">:</tt> <tt class="py-op">-</tt><tt class="py-number">6.54</tt><tt class="py-op">,</tt> <tt class="py-string">'P'</tt><tt class="py-op">:</tt> <tt class="py-number">20.26</tt><tt class="py-op">,</tt> <tt class="py-string">'S'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'R'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'T'</tt><tt class="py-op">:</tt> <tt class="py-number">33.60</tt><tt class="py-op">,</tt> <tt class="py-string">'W'</tt><tt class="py-op">:</tt> <tt class="py-number">24.68</tt><tt class="py-op">,</tt> <tt class="py-string">'V'</tt><tt class="py-op">:</tt> <tt class="py-op">-</tt><tt class="py-number">6.54</tt><tt class="py-op">,</tt> <tt class="py-string">'Y'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">}</tt><tt class="py-op">,</tt><tt class="py-string">'E'</tt><tt class="py-op">:</tt> <tt class="py-op">{</tt><tt class="py-string">'A'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'C'</tt><tt class="py-op">:</tt> <tt class="py-number">44.94</tt><tt class="py-op">,</tt> <tt class="py-string">'E'</tt><tt class="py-op">:</tt> <tt class="py-number">33.60</tt><tt class="py-op">,</tt> <tt class="py-string">'D'</tt><tt class="py-op">:</tt> <tt class="py-number">20.26</tt><tt class="py-op">,</tt> <tt class="py-string">'G'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'F'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'I'</tt><tt class="py-op">:</tt> <tt class="py-number">20.26</tt><tt class="py-op">,</tt> <tt class="py-string">'H'</tt><tt class="py-op">:</tt> <tt class="py-op">-</tt><tt class="py-number">6.54</tt><tt class="py-op">,</tt> <tt class="py-string">'K'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'M'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'L'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'N'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'Q'</tt><tt class="py-op">:</tt> <tt class="py-number">20.26</tt><tt class="py-op">,</tt> <tt class="py-string">'P'</tt><tt class="py-op">:</tt> <tt class="py-number">20.26</tt><tt class="py-op">,</tt> <tt class="py-string">'S'</tt><tt class="py-op">:</tt> <tt class="py-number">20.26</tt><tt class="py-op">,</tt> <tt class="py-string">'R'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'T'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'W'</tt><tt class="py-op">:</tt> <tt class="py-op">-</tt><tt class="py-number">14.03</tt><tt class="py-op">,</tt> <tt class="py-string">'V'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'Y'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">}</tt><tt class="py-op">,</tt> <tt class="py-string">'D'</tt><tt class="py-op">:</tt> <tt class="py-op">{</tt><tt class="py-string">'A'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'C'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'E'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'D'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'G'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'F'</tt><tt class="py-op">:</tt> <tt class="py-op">-</tt><tt class="py-number">6.54</tt><tt class="py-op">,</tt> <tt class="py-string">'I'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'H'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'K'</tt><tt class="py-op">:</tt> <tt class="py-op">-</tt><tt class="py-number">7.49</tt><tt class="py-op">,</tt> <tt class="py-string">'M'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'L'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'N'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'Q'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'P'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'S'</tt><tt class="py-op">:</tt> <tt class="py-number">20.26</tt><tt class="py-op">,</tt> <tt class="py-string">'R'</tt><tt class="py-op">:</tt> <tt class="py-op">-</tt><tt class="py-number">6.54</tt><tt class="py-op">,</tt> <tt class="py-string">'T'</tt><tt class="py-op">:</tt> <tt class="py-op">-</tt><tt class="py-number">14.03</tt><tt class="py-op">,</tt> <tt class="py-string">'W'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'V'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'Y'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">}</tt><tt class="py-op">,</tt> <tt class="py-string">'G'</tt><tt class="py-op">:</tt> <tt class="py-op">{</tt><tt class="py-string">'A'</tt><tt class="py-op">:</tt> <tt class="py-op">-</tt><tt class="py-number">7.49</tt><tt class="py-op">,</tt> <tt class="py-string">'C'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'E'</tt><tt class="py-op">:</tt> <tt class="py-op">-</tt><tt class="py-number">6.54</tt><tt class="py-op">,</tt> <tt class="py-string">'D'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'G'</tt><tt class="py-op">:</tt> <tt class="py-number">13.34</tt><tt class="py-op">,</tt> <tt class="py-string">'F'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'I'</tt><tt class="py-op">:</tt> <tt class="py-op">-</tt><tt class="py-number">7.49</tt><tt class="py-op">,</tt> <tt class="py-string">'H'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'K'</tt><tt class="py-op">:</tt> <tt class="py-op">-</tt><tt class="py-number">7.49</tt><tt class="py-op">,</tt> <tt class="py-string">'M'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'L'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'N'</tt><tt class="py-op">:</tt> <tt class="py-op">-</tt><tt class="py-number">7.49</tt><tt class="py-op">,</tt> <tt class="py-string">'Q'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'P'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'S'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'R'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'T'</tt><tt class="py-op">:</tt> <tt class="py-op">-</tt><tt class="py-number">7.49</tt><tt class="py-op">,</tt> <tt class="py-string">'W'</tt><tt class="py-op">:</tt> <tt class="py-number">13.34</tt><tt class="py-op">,</tt> <tt class="py-string">'V'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'Y'</tt><tt class="py-op">:</tt> <tt class="py-op">-</tt><tt class="py-number">7.49</tt><tt class="py-op">}</tt><tt class="py-op">,</tt> <tt class="py-string">'F'</tt><tt class="py-op">:</tt> <tt class="py-op">{</tt><tt class="py-string">'A'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'C'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'E'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'D'</tt><tt class="py-op">:</tt> <tt class="py-number">13.34</tt><tt class="py-op">,</tt> <tt class="py-string">'G'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'F'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'I'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'H'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'K'</tt><tt class="py-op">:</tt> <tt class="py-op">-</tt><tt class="py-number">14.03</tt><tt class="py-op">,</tt> <tt class="py-string">'M'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'L'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'N'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'Q'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'P'</tt><tt class="py-op">:</tt> <tt class="py-number">20.26</tt><tt class="py-op">,</tt> <tt class="py-string">'S'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'R'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'T'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'W'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'V'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'Y'</tt><tt class="py-op">:</tt> <tt class="py-number">33.601</tt><tt class="py-op">}</tt><tt class="py-op">,</tt> <tt class="py-string">'I'</tt><tt class="py-op">:</tt> <tt class="py-op">{</tt><tt class="py-string">'A'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'C'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'E'</tt><tt class="py-op">:</tt> <tt class="py-number">44.94</tt><tt class="py-op">,</tt> <tt class="py-string">'D'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'G'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'F'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'I'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'H'</tt><tt class="py-op">:</tt> <tt class="py-number">13.34</tt><tt class="py-op">,</tt> <tt class="py-string">'K'</tt><tt class="py-op">:</tt> <tt class="py-op">-</tt><tt class="py-number">7.49</tt><tt class="py-op">,</tt> <tt class="py-string">'M'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'L'</tt><tt class="py-op">:</tt> <tt class="py-number">20.26</tt><tt class="py-op">,</tt> <tt class="py-string">'N'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'Q'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'P'</tt><tt class="py-op">:</tt> <tt class="py-op">-</tt><tt class="py-number">1.88</tt><tt class="py-op">,</tt> <tt class="py-string">'S'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'R'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'T'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt class="py-op">,</tt> <tt class="py-string">'W'</tt><tt class="py-op">:</tt> <tt class="py-number">1.0</tt><tt 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