ID 7LES_DROME STANDARD; PRT; 2554 AA.
AC P13368;
DT 01-JAN-1990 (Rel. 13, Created)
DT 01-JAN-1990 (Rel. 13, Last sequence update)
DT 01-NOV-1997 (Rel. 35, Last annotation update)
DE SEVENLESS PROTEIN (EC 2.7.1.112).
GN SEV.
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Arthropoda; Tracheata; Hexapoda; Insecta;
OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila.
RN [1]
RP SEQUENCE FROM N.A.
RC STRAIN=CANTON-S;
RX MEDLINE; 88282538.
RA BASLER K., HAFEN E.;
RT "Control of photoreceptor cell fate by the sevenless protein requires
RT a functional tyrosine kinase domain.";
RL Cell 54:299-311(1988).
RN [2]
RP SEQUENCE FROM N.A.
RC STRAIN=OREGON-R;
RX MEDLINE; 88329706.
RA BOWTELL D.L.L., SIMON M.A., RUBIN G.M.;
RT "Nucleotide sequence and structure of the sevenless gene of
RT Drosophila melanogaster.";
RL Genes Dev. 2:620-634(1988).
RN [3]
RP IDENTIFICATION OF FN-III REPEATS.
RX MEDLINE; 90199889.
RA NORTON P.A., HYNES R.O., RESS D.J.G.;
RT "Sevenless: seven found?";
RL Cell 61:15-16(1990).
CC -!- FUNCTION: RECEPTOR FOR AN EXTRACELLULAR SIGNAL REQUIRED TO
CC INSTRUCT A CELL TO DIFFERENTIATE INTO A R7 PHOTORECEPTOR. THE
CC LIGAND FOR SEV IS THE BOSS (BRIDE OF SEVENLESS) PROTEIN ON THE
CC SURFACE OF THE NEIGHBORING R8 CELL.
CC -!- CATALYTIC ACTIVITY: ATP + A PROTEIN TYROSINE = ADP +
CC PROTEIN TYROSINE PHOSPHATE.
CC -!- SUBUNIT: MAY FORM A COMPLEX WITH DRK AND SOS.
CC -!- SIMILARITY: BELONGS TO THE INSULIN RECEPTOR FAMILY OF TYROSINE-
CC PROTEIN KINASES. SEVENLESS SUBFAMILY.
CC -!- SIMILARITY: CONTAINS 7 FIBRONECTIN TYPE III-LIKE DOMAINS.
CC -!- CAUTION: UNCLEAR WHETHER THE POTENTIAL MEMBRANE SPANNING REGION
CC NEAR THE N-TERMINUS IS PRESENT AS A TRANSMEMBRANE DOMAIN IN THE
CC NATIVE PROTEIN OR SERVES AS A CLEAVED SIGNAL SEQUENCE.
CC --------------------------------------------------------------------------
CC This SWISS-PROT entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use by non-profit institutions as long as its content is in no way
CC modified and this statement is not removed. Usage by and for commercial
CC entities requires a license agreement (See http://www.isb-sib.ch/announce/
CC or send an email to license@isb-sib.ch).
CC --------------------------------------------------------------------------
DR EMBL; X13666; CAA31960.1; ALT_INIT.
DR EMBL; J03158; AAA28882.1; -.
DR PIR; A28912; TVFF7L.
DR HSSP; P11362; 1FGI.
DR FLYBASE; FBgn0003366; sev.
DR PFAM; PF00041; fn3; 6.
DR PFAM; PF00069; pkinase; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
KW Transferase; Tyrosine-protein kinase; Transmembrane; ATP-binding;
KW Phosphorylation; Receptor; Vision; Repeat.
FT DOMAIN 1 2123 EXTRACELLULAR (POTENTIAL).
FT TRANSMEM 102 122 POTENTIAL.
FT TRANSMEM 2124 2147 POTENTIAL.
FT DOMAIN 2148 2554 CYTOPLASMIC (POTENTIAL).
FT DOMAIN 311 431 FIBRONECTIN TYPE-III.
FT DOMAIN 436 528 FIBRONECTIN TYPE-III.
FT DOMAIN 822 921 FIBRONECTIN TYPE-III.
FT DOMAIN 1298 1392 FIBRONECTIN TYPE-III.
FT DOMAIN 1680 1794 FIBRONECTIN TYPE-III.
FT DOMAIN 1797 1897 FIBRONECTIN TYPE-III.
FT DOMAIN 1898 1988 FIBRONECTIN TYPE-III.
FT DOMAIN 2038 2046 POLY-ARG.
FT DOMAIN 2209 2485 PROTEIN KINASE.
FT NP_BIND 2215 2223 ATP (BY SIMILARITY).
FT BINDING 2242 2242 ATP (BY SIMILARITY).
FT MUTAGEN 2242 2242 K->M: INACTIVATES THE PROTEIN.
FT MOD_RES 2380 2380 PHOSPHORYLATION (AUTO-) (BY SIMILARITY).
FT CARBOHYD 30 30 POTENTIAL.
FT CARBOHYD 129 129 POTENTIAL.
FT CARBOHYD 481 481 POTENTIAL.
FT CARBOHYD 505 505 POTENTIAL.
FT CARBOHYD 617 617 POTENTIAL.
FT CARBOHYD 647 647 POTENTIAL.
FT CARBOHYD 966 966 POTENTIAL.
FT CARBOHYD 1228 1228 POTENTIAL.
FT CARBOHYD 1313 1313 POTENTIAL.
FT CARBOHYD 1353 1353 POTENTIAL.
FT CARBOHYD 1550 1550 POTENTIAL.
FT CARBOHYD 1557 1557 POTENTIAL.
FT CARBOHYD 1639 1639 POTENTIAL.
FT CARBOHYD 1725 1725 POTENTIAL.
FT CARBOHYD 1756 1756 POTENTIAL.
FT CARBOHYD 1804 1804 POTENTIAL.
FT CARBOHYD 1889 1889 POTENTIAL.
FT CARBOHYD 1947 1947 POTENTIAL.
FT CARBOHYD 2073 2073 POTENTIAL.
FT VARIANT 392 392 M -> V.
FT VARIANT 1668 1668 A -> V.
FT VARIANT 1703 1703 N -> H.
FT VARIANT 1730 1730 R -> K.
FT VARIANT 1731 1731 G -> E.
FT VARIANT 1741 1741 V -> M.
FT VARIANT 2271 2271 R -> C.
FT CONFLICT 1823 1823 E -> Q (IN REF. 2).
SQ SEQUENCE 2554 AA; 287107 MW; 1143D891 CRC32;
MTMFWQQNVD HQSDEQDKQA KGAAPTKRLN ISFNVKIAVN VNTKMTTTHI NQQAPGTSSS
SSNSQNASPS KIVVRQQSSS FDLRQQLARL GRQLASGQDG HGGISTILII NLLLLILLSI
CCDVCRSHNY TVHQSPEPVS KDQMRLLRPK LDSDVVEKVA IWHKHAAAAP PSIVEGIAIS
SRPQSTMAHH PDDRDRDRDP SEEQHGVDER MVLERVTRDC VQRCIVEEDL FLDEFGIQCE
KADNGEKCYK TRCTKGCAQW YRALKELESC QEACLSLQFY PYDMPCIGAC EMAQRDYWHL
QRLAISHLVE RTQPQLERAP RADGQSTPLT IRWAMHFPEH YLASRPFNIQ YQFVDHHGEE
LDLEQEDQDA SGETGSSAWF NLADYDCDEY YMCEILEALI PYTQYRFRFE LPFGENRDEV
LYSPATPAYQ TPPEGAPISA PVIEHLMGLD DSHLAVHWHP GRFTNGPIEG YRLRLSSSEG
NATSEQLVPA GRGSYIFSQL QAGTNYTLAL SMINKQGEGP VAKGFVQTHS ARNEKPAKDL
TESVLLVGRR AVMWQSLEPA GENSMIYQSQ EELADIAWSK REQQLWLLNV HGELRSLKFE
SGQMVSPAQQ LKLDLGNISS GRWVPRRLSF DWLHHRLYFA MESPERNQSS FQIISTDLLG
ESAQKVGESF DLPVEQLEVD ALNGWIFWRN EESLWRQDLH GRMIHRLLRI RQPGWFLVQP
QHFIIHLMLP QEGKFLEISY DGGFKHPLPL PPPSNGAGNG PASSHWQSFA LLGRSLLLPD
SGQLILVEQQ GQAASPSASW PLKNLPDCWA VILLVPESQP LTSAGGKPHS LKALLGAQAA
KISWKEPERN PYQSADAARS WSYELEVLDV ASQSAFSIRN IRGPIFGLQR LQPDNLYQLR
VRAINVDGEP GEWTEPLAAR TWPLGPHRLR WASRQGSVIH TNELGEGLEV QQEQLERLPG
PMTMVNESVG YYVTGDGLLH CINLVHSQWG CPISEPLQHV GSVTYDWRGG RVYWTDLARN
CVVRMDPWSG SRELLPVFEA NFLALDPRQG HLYYATSSQL SRHGSTPDEA VTYYRVNGLE
GSIASFVLDT QQDQLFWLVK GSGALRLYRA PLTAGGDSLQ MIQQIKGVFQ AVPDSLQLLR
PLGALLWLER SGRRARLVRL AAPLDVMELP TPDQASPASA LQLLDPQPLP PRDEGVIPMT
VLPDSVRLDD GHWDDFHVRW QPSTSGGNHS VSYRLLLEFG QRLQTLDLST PFARLTQLPQ
AQLQLKISIT PRTAWRSGDT TRVQLTTPPV APSQPRRLRV FVERLATALQ EANVSAVLRW
DAPEQGQEAP MQALEYHISC WVGSELHEEL RLNQSALEAR VEHLQPDQTY HFQVEARVAA
TGAAAGAASH ALHVAPEVQA VPRVLYANAE FIGELDLDTR NRRRLVHTAS PVEHLVGIEG
EQRLLWVNEH VELLTHVPGS APAKLARMRA EVLALAVDWI QRIVYWAELD ATAPQAAIIY
RLDLCNFEGK ILQGERVWST PRGRLLKDLV ALPQAQSLIW LEYEQGSPRN GSLRGRNLTD
GSELEWATVQ PLIRLHAGSL EPGSETLNLV DNQGKLCVYD VARQLCTASA LRAQLNLLGE
DSIAGQLAQD SGYLYAVKNW SIRAYGRRRQ QLEYTVELEP EEVRLLQAHN YQAYPPKNCL
LLPSSGGSLL KATDCEEQRC LLNLPMITAS EDCPLPIPGV RYQLNLTLAR GPGSEEHDHG
VEPLGQWLLG AGESLNLTDL LPFTRYRVSG ILSSFYQKKL ALPTLVLAPL ELLTASATPS
PPRNFSVRVL SPRELEVSWL PPEQLRSESV YYTLHWQQEL DGENVQDRRE WEAHERRLET
AGTHRLTGIK PGSGYSLWVQ AHATPTKSNS SERLHVRSFA ELPELQLLEL GPYSLSLTWA
GTPDPLGSLQ LECRSSAEQL RRNVAGNHTK MVVEPLQPRT RYQCRLLLGY AATPGAPLYH
GTAEVYETLG DAPSQPGKPQ LEHIAEEVFR VTWTAARGNG APIALYNLEA LQARSDIRRR
RRRRRRNSGG SLEQLPWAEE PVVVEDQWLD FCNTTELSCI VKSLHSSRLL LFRVRARSLE
HGWGPYSEES ERVAEPFVSP EKRGSLVLAI IAPAAIVSSC VLALVLVRKV QKRRLRAKKL
LQQSRPSIWS NLSTLQTQQQ LMAVRNRAFS TTLSDADIAL LPQINWSQLK LLRFLGSGAF
GEVYEGQLKT EDSEEPQRVA IKSLRKGASE FAELLQEAQL MSNFKHENIV RLVGICFDTE
SISLIMEHME AGDLLSYLRA ARATSTQEPQ PTAGLSLSEL LAMCIDVANG CSYLEDMHFV
HRDLACRNCL VTESTGSTDR RRTVKIGDFG LARDIYKSDY YRKEGEGLLP VRWMSPESLV
DGLFTTQSDV WAFGVLCWEI LTLGQQPYAA RNNFEVLAHV KEGGRLQQPP MCTEKLYSLL
LLCWRTDPWE RPSFRRCYNT LHAISTDLRR TQMASATADT VVSCSRPEFK VRFDGQPLEE
HREHNERPED ENLTLREVPL KDKQLYANEG VSRL
//
