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id="path1085" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 270.6392 443.2190 L 270.6442 449.2540 L 270.6432 448.7180 " id="path1086" /> <text style="font-size:12.000;font-family:Times;" transform="scale(0.757118,0.757118)" id="text1087" x="90.8439217" y="582.233169">O</text> <text style="font-size:12.000;font-family:Times;" transform="scale(0.757118,0.757118)" id="text1089" x="383.426622" y="582.633315">O</text> <text style="font-size:12.000;font-family:Times;" transform="scale(0.757118,0.757118)" id="text1091" x="317.986342" y="582.633315">HO</text> <text style="font-size:12.000;font-family:Times;" transform="scale(0.757118,0.757118)" id="text1093" x="60.4787662" y="561.813551">O</text> <text style="font-size:12.000;font-family:Times;" transform="scale(0.757118,0.757118)" id="text1095" x="353.061447" y="562.213759">O</text> <text style="font-size:12.000;font-family:Times;" transform="scale(0.757118,0.757118)" id="text1097" x="60.4787662" y="602.477005">OH</text> <text style="font-size:12.000;font-family:Times;" transform="scale(0.757118,0.757118)" id="text1099" x="353.061447" y="602.877213">OH</text> <text style="font-size:12.000;font-family:Times;" transform="scale(0.757118,0.757118)" id="text1101" x="61.9778660" y="582.233169">P</text> <text style="font-size:12.000;font-family:Times;" transform="scale(0.757118,0.757118)" id="text1103" x="354.560623" y="582.633315">P</text> <g id="g1105" style="font-size:12.000;" transform="translate(-7.569849,-7.569862)"> <path style="stroke:#000000; stroke-width:1; fill:none" d="M 55.6484 433.913L 55.6534 439.948L 55.6524 439.412" id="path1106" /> <path style="stroke:#000000; stroke-width:1; fill:none" d="M 57.6824 433.913L 57.6874 439.948L 57.6874 439.412" id="path1107" /> </g> <g id="g1108" style="font-size:12.000;" transform="translate(-7.569849,-7.569862)"> <path style="stroke:#000000; stroke-width:1; fill:none" d="M 277.168 434.216L 277.173 440.251L 277.172 439.715" id="path1109" /> <path style="stroke:#000000; stroke-width:1; fill:none" d="M 279.202 434.216L 279.207 440.251L 279.207 439.715" id="path1110" /> </g> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,392.4950,102.3720)" id="text1111">OH</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,385.8340,202.7660)" id="text1113">OH</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,385.8340,302.8610)" id="text1115">OH</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,385.8340,252.9920)" id="text1117">OH</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,385.8340,353.0870)" id="text1119">OH</text> <text style="font-size:12.000;font-family:Times;" transform="scale(0.757118,0.757118)" id="text1121" x="144.992163" y="582.233169">O</text> <text style="font-size:12.000;font-family:Times;" transform="scale(0.757118,0.757118)" id="text1123" x="437.575397" y="582.633315">O</text> <text style="font-size:12.000;font-family:Times;" transform="translate(96.55040,148.4240)" id="text1125">a1</text> <text style="font-size:12.000;font-family:Times;" transform="translate(420.3580,202.5110)" id="text1127">z1</text> <text style="font-size:12.000;font-family:Times;" id="text1129" x="421.071014" y="302.338974">x1</text> <text style="font-size:12.000;font-family:Times;" id="text1131" x="421.071014" y="352.564957">w1</text> <text style="font-size:12.000;font-family:Times;" id="text1133" x="421.071014" y="252.468948">y1</text> <text style="font-size:12.000;font-family:Times;" transform="translate(110.1600,152.6990)" id="text1135">b1</text> <text style="font-size:12.000;font-family:Times;" transform="translate(143.4990,156.7850)" id="text1137">c1</text> <text style="font-size:12.000;font-family:Times;" transform="translate(158.2840,160.7150)" id="text1139">d1</text> <text style="font-size:12.000;font-family:Times;" transform="translate(336.8530,59.06180)" id="text1141">x1</text> <text style="font-size:12.000;font-family:Times;" transform="translate(368.1610,59.86480)" id="text1143">y1</text> <text style="font-size:12.000;font-family:Times;" transform="translate(382.0600,66.20080)" id="text1145">z1</text> <text style="font-size:12.000;font-family:Times;" transform="translate(319.2660,54.78680)" id="text1147">w1</text> <text style="font-size:12.000;font-family:Times;" transform="scale(0.934426,0.934426)" id="text1149" x="37.4169702" y="437.851396">Canonical monomer</text> <text style="font-size:12.000;font-family:Times;" id="text1151" x="157.782368" y="437.851396" transform="scale(0.934426,0.934426)">Normally, the left end of a nucleic acid, after capping, is:</text> <text style="font-size:12.000;font-family:Times;" id="text1153" x="161.639145" y="479.929085">Thus, if 5'OH is required, subtract HPO3 from</text> <text style="font-size:12.000;font-family:Times;" id="text1155" x="161.185150" y="493.777077">left end-bearing fragments (like a, b, c, d)</text> <text style="font-size:12.000;font-family:Times;" id="text1158" x="161.024139" y="435.413124">+ OH</text> <path style="font-size:12.000;fill:none;stroke:#000000;stroke-dasharray:6.0000 3 ;" d="M 258.6092 415.3490 L 298.2822 415.3490 L 298.2822 460.4940 L 258.6092 460.4940 L 258.6092 415.3490 z " id="path1160" /> <path style="font-size:12.000;fill:none;stroke:#000000;stroke-width:0.904839;stroke-dasharray:5.4290 2.7145 ;" d="M 341.3335 468.5830 L 373.8151 468.5830 L 373.8151 483.1750 L 341.3335 483.1750 L 341.3335 468.5830 z " id="path1161" /> <text style="font-size:12.000;font-family:Times;" id="text1162" x="88.6153011" y="26.7887955">All the fragments below bear one negative charge</text> <text style="font-size:12.000;font-family:Times;" transform="scale(0.667197,0.667199)" id="text1164" x="82.2466179" y="56.0024441">(not formally represented on the sequence/fragments because it can be floating at any valid place)</text> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 294.196 350.806L 285.482 344.048L 276.989 350.673L 264.108 350.673" id="path1169" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 125.629 233.475L 125.629 268.511L 119.076 249.825L 109.247 249.825" id="path1171" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 125.629 183.605L 125.629 218.642L 119.076 199.956L 109.247 199.956" id="path1172" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 125.629 283.7L 125.629 318.737L 119.076 300.051L 109.247 300.051" id="path1173" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 125.629 334.282L 125.629 369.319L 119.076 350.633L 109.247 350.633" id="path1174" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 125.629 233.475L 125.629 268.511L 119.076 249.825L 109.247 249.825" id="path1175" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 125.629 183.605L 125.629 218.642L 119.076 199.956L 109.247 199.956" id="path1176" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 125.629 283.7L 125.629 318.737L 119.076 300.051L 109.247 300.051" id="path1177" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 125.629 334.282L 125.629 369.319L 119.076 350.633L 109.247 350.633" id="path1178" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 125.855 249.811L 135.832 249.811L 134.945 249.811" id="path1179" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 125.855 300.036L 135.832 300.036L 134.945 300.036" id="path1180" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 125.855 350.618L 135.832 350.618L 134.945 350.618" id="path1181" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 62.4454 249.811L 71.7004 249.811L 70.8774 249.811" id="path1182" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 62.4454 199.94L 71.7004 199.94L 70.8774 199.94" id="path1183" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 62.4454 300.036L 71.7004 300.036L 70.8774 300.036" id="path1184" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 62.4454 350.618L 71.7004 350.618L 70.8774 350.618" id="path1185" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 85.3814 249.811L 94.6365 249.811L 93.8144 249.811" id="path1186" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 85.3814 199.94L 94.6365 199.94L 93.8144 199.94" id="path1187" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 85.3814 300.036L 94.6365 300.036L 93.8144 300.036" id="path1188" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 85.3814 350.618L 94.6365 350.618L 93.8144 350.618" id="path1189" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 78.5884 254.942L 78.5934 260.977L 78.5934 260.441" id="path1190" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 78.5884 205.073L 78.5934 211.108L 78.5934 210.571" id="path1191" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 78.5884 305.168L 78.5934 311.203L 78.5934 310.666" id="path1192" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 78.5884 355.75L 78.5934 361.785L 78.5934 361.248" id="path1193" /> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,46.24840,202.9750)" id="text1194">HO</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,46.24840,252.9350)" id="text1196">HO</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,46.24840,303.2310)" id="text1198">HO</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,46.24840,353.7800)" id="text1200">HO</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,98.24940,252.8450)" id="text1202">O</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,98.24940,202.9750)" id="text1204">O</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,98.24940,303.0710)" id="text1206">O</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,98.24940,353.6520)" id="text1208">O</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,75.25840,237.3850)" id="text1210">O</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,75.25840,187.5150)" id="text1212">O</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,75.25840,287.6100)" id="text1214">O</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,75.25840,338.1920)" id="text1216">O</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,75.25840,268.1720)" id="text1218">OH</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,75.25840,218.3020)" id="text1220">OH</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,75.25840,318.3970)" id="text1222">OH</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,75.25840,368.9790)" id="text1224">OH</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,76.39440,252.8450)" id="text1226">P</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,76.39440,202.9750)" id="text1228">P</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,76.39440,303.0710)" id="text1230">P</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,76.39440,353.6520)" id="text1232">P</text> <g id="g1234" style="font-size:12.000;"> <path style="stroke:#000000; stroke-width:1; fill:none" d="M 77.5474 238.369L 77.5524 244.404L 77.5524 243.868" id="path1235" /> <path style="stroke:#000000; stroke-width:1; fill:none" d="M 79.5825 238.369L 79.5874 244.404L 79.5874 243.868" id="path1236" /> </g> <g id="g1237" style="font-size:12.000;"> <path style="stroke:#000000; stroke-width:1; fill:none" d="M 77.5474 188.5L 77.5524 194.535L 77.5524 193.998" id="path1238" /> <path style="stroke:#000000; stroke-width:1; fill:none" d="M 79.5825 188.5L 79.5874 194.535L 79.5874 193.998" id="path1239" /> </g> <g id="g1240" style="font-size:12.000;"> <path style="stroke:#000000; stroke-width:1; fill:none" d="M 77.5474 288.595L 77.5524 294.63L 77.5524 294.094" id="path1241" /> <path style="stroke:#000000; stroke-width:1; fill:none" d="M 79.5825 288.595L 79.5874 294.63L 79.5874 294.094" id="path1242" /> </g> <g id="g1243" style="font-size:12.000;"> <path style="stroke:#000000; stroke-width:1; fill:none" d="M 77.5474 339.177L 77.5524 345.212L 77.5524 344.675" id="path1244" /> <path style="stroke:#000000; stroke-width:1; fill:none" d="M 79.5825 339.177L 79.5874 345.212L 79.5874 344.675" id="path1245" /> </g> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,122.7270,231.6450)" id="text1246">B1</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,122.7270,181.7760)" id="text1248">B1</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,122.7270,281.8710)" id="text1250">B1</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,122.7270,332.4530)" id="text1252">B1</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.881001,0,0,0.881001,35.80990,204.0240)" id="text1254">5'</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.881001,0,0,0.881001,35.80990,253.9840)" id="text1256">5'</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.881001,0,0,0.881001,35.80990,304.2800)" id="text1258">5'</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.881001,0,0,0.881001,35.80990,354.8290)" id="text1260">5'</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,140.3290,252.8450)" id="text1262">O</text> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 150.217 300.036L 159.472 300.036L 158.65 300.036" id="path1264" /> <path style="font-size:12.000;fill:none;stroke:#000000;" d="M 166.361 305.168L 166.366 311.203L 166.365 310.666" id="path1265" /> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,140.3290,303.0710)" id="text1266">O</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,163.0310,287.6100)" id="text1268">O</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,163.0310,318.3970)" id="text1270">OH</text> <text style="font-size:12.000;font-family:Times;" transform="matrix(0.757118,0,0,0.757118,164.1660,303.0710)" id="text1272">P</text> <g id="g1274" style="font-size:12.000;"> <path style="stroke:#000000; stroke-width:1; fill:none" d="M 165.32 288.595L 165.325 294.63L 165.324 294.094" id="path1275" /> <path style="stroke:#000000; stroke-width:1; fill:none" d="M 167.354 288.595L 167.359 294.63L 167.359 294.094" id="path1276" /> </g> <g id="g1277" style="font-size:12.000;"> <path style="stroke:#000000; stroke-width:1; fill:none" d="M 150.217 350.618L 159.472 350.618L 158.65 350.618" id="path1278" /> <path style="stroke:#000000; stroke-width:1; fill:none" d="M 173.154 350.618L 182.409 350.618L 181.586 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